|PHYSICAL FATIGUE AND COENZYME Q10|
"Antifatigue effects of coenzyme Q10 during physical fatigue," Mizuno K, Tanaka M, et al, Nutrition, 2008 Feb 11; [Epub ahead of print]
This is a randomized, double-blinded, placebo-controlled, three crossover study involving 17 healthy volunteers. Supplementation with coenzyme Q10 (CoQ10) for a period of 8 days was found to significantly reduce subjective feelings of fatigue and improve physical performance.
Subjects underwent fatigue-inducing workload trials on a bicycle at fixed workloads twice for 2 hours, followed by 4 hours of rest. Thirty minutes after the start of the physical tasks (30-minute trial) and 30 minutes before the end of the tasks (210-minute trial), subjects performed non-workload trials with maximum velocity for 10 seconds.
Subjects were randomized to receive 3 different treatments:
1) 100 mg/day coenzyme Q10
2) 300 mg/day coenzyme Q10
Results found that compared with placebo, supplementation with 300 mg/day coenzyme Q10 led to a higher change in maximum velocity from the 30-minute to the 210-minute trial. Furthermore, after taking 300 mg/day coenzyme Q10, subjective perception of fatigue was significantly alleviated, as compared to placebo.
CoQ10 is found in high concentrations in the heart, liver, kidney, and pancreas. About 50% of the CoQ10 in the body is found within the cell mitochondria, where energy is generated on a continuous basis, and where CoQ10 has three major functions: to help convert dietary nutrients into energy; to help quench some of the free radicals generated in the energy making process; and to help protect the integrity of the mitochondrial membrane. Use of any statin drug destroys stores of CoQ10. This is particularly important in the heart where energy output is high and therefore the need/concentration of CoQ10 is also high.
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