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Dr. Gregory Pais, ND
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Home arrow Blog arrow KEEP YOUR KNEE
"Total joint replacement after glucosamine sulphate treatment in knee osteoarthritis: results of a mean 8-year observation of patients from two previous 3-year, randomised, placebo-controlled trials," Bruyere O, Pavelka K, et al, Osteoarthritis Cartilage, 2008; 16(2): 254-60.
Glucosamine sulfate can prevent the need for total knee joint replacement. In a study involving 275 patients with osteoarthritis of the knee, supplementation with glucosamine sulfate for at least 12 months was found to reduce the likelihood of requiring a total joint replacement over a 5-year period.

Subjects were selected from 2 previous studies in which they either received glucosamine sulfate (144 people) or a placebo (131 people) for at least 12 months, and up to 3 years. Patients were followed up with for approximately 5 years from the time the trials were terminated and the treatment was discontinued.

Results found twice as many total knee replacement surgeries had occurred in the placebo group (14.5% of the group, 19 out of 131 subjects), as compared to the group of subjects who had formerly received glucosamine sulfate (6.3% of the group, 9 out of 144 subjects). The risk of total knee joint replacement was significantly decreased among subjects who formerly received glucosamine sulfate.

These results were confirmed by a test survival analysis, which found a significantly decreased cumulative incidence of total knee replacements in patients who had received glucosamine sulfate. Furthermore, subjects who had previously received glucosamine sulfate had less use of medications used to alleviate symptoms and less use of other health resources in general.

Glucosamine sulfate provides nutrition for joint cartilage. Across the board I've found many individuals previously diagnosed with 'arthritis' and put on NSAIDs indefinitely to respond very well to a high quality glucosamine sulfate in sufficient amounts. Now I will add knee joint prevention to the list of benefits.


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